Many are uninformed that arthritis conditions can come in varying forms. There are actually 100 different types of arthritis and some of these can affect anyone regardless of age and gender. Rheumatoid arthritis is probably the most popular forms of arthritis condition which could be incapacitating for the affected individual. If you are not aware of the indications of the disease, it may be hard for you to assess if you are suffering with it. That is the reason why you have to learn what triggers arthritis, its signs along with the available treatment solutions. As for rheumatoid arthritis, the following are some of the most important details that you need to know.
Autoimmune Factors
Rheumatoid arthritis is a prominent trait found within the blood and this can be considered as an antibody that holds certain kinds of antigens. These antigens include various probable risks to the body?s defense system. For example, bacteria, foreign blood cells, toxins and foreign tissues are all considered as antigens. The antibodies as well as the immune system secure the body against these trespassers to ensure that the body is free from the health issues. Nevertheless, if more antigens exist than antibodies, this can affect the immune system and result in numerous conditions. In rheumatoid arthritis, the lining in the joints contain activated cells which causes chronic inflammation and emotional stress.
Hormonal Changes
Experts believe that an individual?s hypothalamus takes on a vital role in the progression of rheumatoid arthritis. The hypothalamus could trigger the stress response called corticotrophin-releasing hormone or CRH. The CRH, on the other hand, will release adrenocoricotropic hormones that can further initiate the production of glucocorticoids through the adrenal cortex. These glucocorticoids operate in unison and it is responsible for the metabolism of fats and protein as well as handles carbohydrates within the body. In the normal functions, these have anti-inflammatory benefits to the body. Nevertheless, in rheumatoid arthritis, the over-stimulation of such hormones as a result of infections or stress can cause increased amount of cortisol. So rather than becoming an anti-inflammatory, it becomes pro-inflammatory because of the response of receptors to the excessive amount of cortisol which is believed to be what causes rheumatoid arthritis.
The Role of HPA Axis and Cortisol
The triggering of the HPA or the hypothalamic-pituitary-adrenal axis caused by acute stress is accumulative by nature which results to negative physiological effects, therefore bringing on irregular glucose metabolism and leads to diabetes and weight problems, irreversible hippocampal damage and depression. These alterations in rheumatoid arthritis may result in a metabolic disease which is accompanied by a jeopardized immune system and excessive amount of cortisol. This can then result in an inactive lifestyle, increased insulin resistance or rapid disease progression, glucose intolerance and heart diseases.
Remember that rheumatoid arthritis can result in considerable alterations in the body which could influence an individual?s life. For this reason it must be discovered during its initial phases to ensure that proper remedy could be used to ease its signs and prevent it from aggravating. You should also understand that all arthritis conditions could be incapacitating so you have to become acquainted with the disease.
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